Intrauterine Insemination (IUI)


Intrauterine insemination (IUI) is a simple treatment which may be used for some causes of infertility.

The success rate is much lower than IVF — however, the simplicity of the treatment cycle is appealing to patients.

The IUI process bypasses the cervix. The semen sample (partner or frozen donor sperm) is “washed” (processed) in the andrology lab to extract the most motile (rapidly moving) sperm. CARE Fertility performs a complete analysis of the semen sample before and after processing. A small tube is placed through the cervix and deposits the sperm in the womb (cavity of the uterus). Many women report mild cramping or no discomfort following the IUI procedure.

A simple, painless process:

  1. A semen specimen is placed in a labeled test tube that contains sperm washing media.

  2. After going through a series of steps for preparation, a highly motile sample of sperm is extracted.

  3. A small flexible tube is placed through the cervix, depositing the washed semen sample into the womb (Figure 5.1).

CARE Fertility

Figure 5.1 IUI process.

 Types of IUI

Natural Cycle IUI

Natural cycle IUI is not recommended for patients with unexplained infertility, but may be an option for patients using donor sperm or couples with a coital factor. The majority of pregnancies occur in the first few cycles of IUI.

Clomiphene Citrate (Clomid) IUI

Clomiphene citrate (Clomid) or Letrazole (Femara) may be an option for couples with unexplained infertility, PCOS or mild male factor infertility. Outcomes are similar with either medication. Both medications increase the risk for twins (8 to 10%). As with natural cycle IUI, most pregnancies occur in the first two to three cycles of treatment.

 Timing is everything

The IUI process depends upon the timing of your body.

At CARE Fertility, we use ultrasound to assess the growth of follicle(s) and at-home ovulation predictor testing to determine the best timing of the IUI procedure.

We offer IUI treatments seven days a week at our Bedford location. Our ability to offer IUIs every day increases your chances for success in your goal of building a family.